Extracellular volume fraction measured by MOLLI: slow infusion versus bolus
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POSTER PRESENTATION
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Extracellular volume fraction measured by MOLLI: slow infusion versus bolus Erik Schelbert1*, Stephen M Testa1, Christopher G Meier1, William J Ceyrolles1, Joshua Levenson1, Alex J Blair2, Kathy S Puntil1, Peter Kellman3, Bobby L Jones1, Daniel R Ludwig1, Hua Zhong1, David Schwartzman1, Sanjeev G Shroff1, Timothy C Wong1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Background Myocardial extracellular volume fraction (Ve) measures from myocardial and blood pool T1 data quantify diffuse fibrosis (Flett, 2010) not detectable by conventional late gadolinium (Gd) enhancement, but require steady state equilibrium between plasma and interstitium. While a bolus with a lengthy infusion produces steady state for Ve measures, it is unclear whether a Gd contrast bolus alone (e.g., Broberg, 2010) is sufficient. Given the relatively slow clearance of Gd, we hypothesized that a simple bolus accurately measures Ve, thus facilitating integration of Ve measurement into CMR workflow routines. Methods In 10 diverse volunteers (ages 20-81, median 33 yr), we compared serial Ve measures from two scans: first, during a constant infusion (0.1 mmol/kg bolus followed by 0.1 mmol/kg diluted in 200mL saline, 200 mL/hr infusion, x1hr), and second, 12-50 min after a bolus (0.2 mmol/kg) on another day. Ve data from a diastolic short axis slice were computed as described by Jerosch-Herold (2008). Steady state during infusion was defined when blood and myocardial T1 varied 0.95; p=NS vs. unity) without bias on Bland-Altman plots. Infusion vs. bolus Ve measures (n=205) across subjects were compared with generalized estimating equations with exchangeable correlation matrices for serial measures.
Results By infusion, the Ve range was 19.3-29.2% with a SD
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