Food Protein Induced Enterocolitis (FPIES) Diagnosis and Management
This unique book is a first-of-its-kind resource, comprehensively guiding readers through the epidemiology, pathophysiology, recent diagnostic criteria, and management options for patients with Food Protein-Induced Enterocolitis Syndrome (FPIES).Food-Prot
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Food Protein Induced Enterocolitis (FPIES)
Terri Faye Brown-Whitehorn Antonella Cianferoni Editors
Food Protein Induced Enterocolitis (FPIES) Diagnosis and Management
Editors Terri Faye Brown-Whitehorn Division of Allergy and Immunology University of Pennsylvania Perelman School of Medicine Children’s Hospital of Philadelphia Philadelphia, PA USA
Antonella Cianferoni Division of Allergy and Immunology University of Pennsylvania Perelman School of Medicine Children’s Hospital of Philadelphia Philadelphia, PA, USA
ISBN 978-3-030-21228-5 ISBN 978-3-030-21229-2 (eBook) https://doi.org/10.1007/978-3-030-21229-2 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Food protein-induced enterocolitis syndrome (FPIES) is a severe condition causing acute vomiting and diarrhea that classically starts 2 hours after an ingestion of a specific food. In some cases, the symptoms can progress to dehydration and shock brought on by low blood pressure and poor blood circulation. The diagnosis of FPIES is a purely clinical one as there are no biomarkers to diagnose with certainty the food allergic reaction in the acute phase or food testing to predict the reactivity to foods. The fact that the diagnosis is clinical is one of the biggest frustrations of parents or caregivers of infants and toddlers. FPIES symptoms are non-specific and are common manifestation of other common pediatric diseases, such as viral infections, sepsis, and pyloric stenosis. Therefore, if the clinician is not well versed and does not collect a focused history when a baby has a reaction, most often, he/she is diagnosed with “stomach flu.” It is indeed not unusual that the parents
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