From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph
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From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph Chih-Kung Lee1*, Chi-Wan Lin2, Shiming Lin3, Adam Shih-Yuan Lee4, Jiun-Yan Wu1, Shu-Sheng Lee1, Wen-Hsin Hsiao5, Shih-Jui Chen1, An-Bang Wang1 1* Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 2 Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan 3 Center for Optoelectronic Biomedicine, National Taiwan University, Taipei, Taiwan 4 Department of Chemistry, Tamkang University, Tamshui, Taiwan 5 AdvanceWave Technologies Inc., Taipei, Taiwan ABSTRACT In this paper, an integrated multifunctional biochip detection system, which we call “OBMorph“, are presented. This unique system integrates several optoelectronic-based biological diagnostic tools such as an ellipsometer, a laser Doppler vibrometer/interferometer, a SPR (surface plasmon resonance) analyzer, an interference microscope, a photon tunneling microscope, an optical coherence tomography unit and a confocal scanning microscope. This OBMorph system, useful as a powerful optical metrology diagnostic tool, can be used at the beginning of sensor chip fabrication, on to signal detecting and monitoring, and to the final biological analysis. The principles and experimental results of this multifunctional biochip detection OBMorph system are presented. In addition, an innovative SARS (Severe Acute Respiratory Syndrome) virus denaturing chemical compound that was derived using the OBMorph system to study biolinker fabrication in biochips, are discussed. Several testing strategies are presented herein which proves the effectiveness of the new chemical compound, biochip technology in denaturing the SARS virus. Analysis under an atomic force microscope confirms the actual breaking down of the virus treated by the chemical compound. The fundamentals of how the chemical compound denatures the virus and renders it toxicity useless, is based on principles of nanotechnology and bio-mechanics. Results from preliminary studies show that this denaturing principle can be also effective against other deadly viruses and even bacteria. Some design strategies and innovative working mechanisms derived from study of this chemical compound which can denature the SARS-CoV, are also discussed. INTRODUCTION Combining MEMS (micro-electro-mechanical systems) and optoelectronic technologies, biomedical diagnostic and analytical instruments available today are becoming more and more powerful and the need to provide instruments which integrates both top-down and bottom-up features are becoming even more crucial.
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An optical detection method, which possesses high sensitivity, a wide bandwidth, and small probe volume requirements, is one of the most competitive technologies in bio/nano metrology today. With an aim to construct a multifunctional detection system, we combined a top-down optical detection technology with a bottoms-up biochip design to create a multifunctional biochip detection system that can be applied to protein b
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