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REVIEW

Functional Electrospun Fibers for Local Therapy of Cancer Jingwen Zhao1 · Wenguo Cui1 Received: 3 June 2020 / Accepted: 11 August 2020 © Donghua University, Shanghai, China 2020

Abstract  Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed. Keywords  Electrospinning · Cancer treatment · Local therapy · Drug delivery · Stimuli-responsive

Introduction Cancer is one of the leading causes of death [1] and a major public health burden globally. Surgery has been the main clinical strategy for some types of cancer [2] and the corresponding instrumentation and techniques have improved rapidly. Despite advances in surgical techniques, post-surgical local tumor recurrence and metastasis may still occur [3], which hence requires the development of effective treatments to eliminate residual tumor cells. Meanwhile, there are some malignant tumors that are possibly locally infiltrated, and cannot be readily resected surgically, for which new treatment methods are demanded [4]. Currently, chemotherapy is the most common method for these conditions due to its high therapeutic efficacy, yet it is often accompanied with complications and side effects [5–7]. Local application of chemotherapeutics can be an ideal approach to address these issues benefiting from the stability and controlled delivery efficacy of drug delivery systems [8, 9].

* Wenguo Cui [email protected] 1



Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, People’s Republic of China

Lately, the use of electrospun fibers has attracted considerable attention as a novel drug delivery system for tumor treatment [10]. Electrospinning has arisen as a promising technique in the field of nanofiber fabrication. With the ability to fabricate various nanostructures such as nanofibers and nanoparticles from a wide variety of materials, this simple and highly effective technique has found its applications in different areas such as electronics, tissue engineering, energy storage, and sensors [11–14]. An electrospinning setup consists of four parts: a syringe containing polymer solutio