Fundamentals of Nuclear Pharmacy
Established as a classic text on nuclear chemistry and pharmacy, Fundamentals of Nuclear Pharmacy has been thoroughly revised with new information added covering innovations in imaging technology and clinical applications in the field. The Sixth Edition a
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Gopal B. Saha
Fundamentals of Nuclear Pharmacy Sixth Edition With 103 illustrations
Gopal B. Saha, PhD Consultant Staff Department of Nuclear Medicine The Cleveland Clinic Foundation Cleveland, OH 44195 USA
ISBN 978-1-4419-5859-4 e-ISBN 978-1-4419-5860-0 DOI 10.1007/978-1-4419-5860-0 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2010934378 # Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer ScienceþBusiness Media (www.springer.com)
To those whose appreciation has made this book successful.
Preface
A new edition of a book is warranted when there is a need to update the book with current information and delete all obsolete information. Although research in nuclear medicine involving molecular imaging has progressed very well over the years through the discovery of newer radiopharmaceuticals, there are only a few radiopharmaceuticals that have been introduced into routine clinical use since the publication of the last edition. Also, some radiopharmaceuticals that were approved for clinical use a few years ago have been discontinued from the market because of the lack of utilization by the clinical community due to poor diagnostic outcomes. All these considerations have been taken into account to update this sixth edition, adding only newer information of potential clinical importance and eliminating the outdated information. Like the past editions, the book is intended to be a textbook on nuclear chemistry and pharmacy for nuclear medicine residents and students and as a reference book for nuclear physicians and radiologists. The basic format of the book remains the same as in previous editions, consisting of 16 chapters. Chapters 1, 2, 4, 6, 11 and 16 have no or only minor changes. Chapter 3 contains two new sections, namely, “Digital Image” and “PET/CT and SPECT/CT”. In Chap. 5, a couple of new generators have been added, including a section on calculation of 82Sr and 85Sr breakthrough, a recent requirement of the Nuclear Regulatory Commission. Several obsolete radiopharmaceuticals have been taken out and a few new ones have been added in Chap. 7, and Tables 8.1 to 8.3 have been updated to reflect these changes. A brief outline of USP Chapter has been included in Chap. 9. Tables 10.2 and 10.4 are updated with
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