Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongoli
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Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.jzus.zju.edu.cn; www.springerlink.com E-mail: [email protected]
Correspondence:
Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group*# Yuan-yuan WEI1,2, Xiao-ye JIN1,2,3, Qiong LAN4, 1,2,3
Wei CUI
1,2,3
, Chong CHEN
1,2
, Ting-ting KONG ,
1,2,3
Yu-xin GUO 1
, Jian-gang CHEN†‡5, Bo-feng ZHU†‡1,2,4
Key Laboratory of Shaanxi Province for Craniofacial Precision
Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China 2
Clinical Research Center of Shaanxi Province for Dental and
Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China 3
College of Medicine and Forensics, Xi’an Jiaotong University Health
Science Center, Xi’an 710061, China 4
Department of Forensic Genetics, School of Forensic Medicine,
Southern Medical University, Guangzhou 510515, China 5
Institute of Forensic Science, Ministry of Public Security,
Beijing 100038, China †
E-mail: [email protected]; [email protected]
https://doi.org/10.1631/jzus.B1800279
To further enrich the genetic data of the Chinese Xinjiang Mongolian group, the genetic distribution and forensic parameters of 19 autosomal short tandem repeats (STRs) were investigated. Altogether, 249 alleles were observed in these 19 STRs. The mean values of the polymorphism information content (PIC), match probability (MP), discrimination power (DP), and probability of exclusion (PE) for these 19 STRs were 0.7775, 0.0699, 0.9301, and 0.6085, ‡
Corresponding authors Project supported by the National Natural Science Foundation of China (No. 81460286) and the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS) (2017), China # Electronic supplementary materials: The online version of this article (https://doi.org/10.1631/jzus.B1800279) contains supplementary materials, which are available to authorized users ORCID: Bo-feng ZHU, https://orcid.org/0000-0001-7877-7387 © Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2019 *
respectively. Additionally, the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163, respectively. Furthermore, population genetic analysis of the Mongolian group and 20 published populations was conducted based on the population data of 15 overlapping STRs. Genetic distances indicated that the Mongolian group had closer genetic similarities with the Uyghur, Xibe, and other Chinese populations rather than the other continental populations. Multidimensional scaling analysis further revealed that the Mongolian group possessed similar genetic distributions as most Chinese populations. To sum it all up, these STRs could be used as an extremely efficient tool for forensic applications in the Xinjiang Mongolian group. STRs, with repeat units of 2–6 bp, are
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