Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
Written by global experts, this book provides a modern comprehensive insight into the pharmacogenetics of treatment of major psychoses: schizophrenia, bipolar disorder and depression. The pharmacogenomics of three categories of the most important psychiat
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Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
Janusz K. Rybakowski • Alessandro Serretti Editors
Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
Editors Janusz K. Rybakowski Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Alessandro Serretti Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy
ISBN 978-3-319-27038-8 ISBN 978-3-319-27040-1 DOI 10.1007/978-3-319-27040-1
(eBook)
Library of Congress Control Number: 2016930560 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Adis is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
Introduction
Psychiatric disorders affect a significant percentage of the population, making the issue of their optimal treatment an extremely important one. A judicious use of pharmacological treatment would be the most appropriate and effective method of help to most of such patients. Interindividual genetic variations can influence the responses of patients to any psychotropic medications; therefore, the results of studies investigating genetic background of such a mechanism could facilitate the effectiveness of the treatment. Pharmacogenetics of the treatment of psychiatric disorders has become a rapidly expanding area in the last two decades. This has been mostly caused by the introduction of molecular genetic methods to the field. The most used approach for pharmacogenetic studies of efficacy and safety of treatment with individual drugs is still a “candidate gene” method. However, recently, genome-wide association studies (GWAS) have also been entering into this subject, exemplified in this book by the GWAS of l
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