Haloperidol withdrawal
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Haloperidol withdrawal Recurrence of chorea-ballismus in an elderly patient: case report An 80-year-old man, who had been diagnosed with hyperglycaemia-induced hemichorea-hemiballismus, initially received insulin treatment. However, despite normal glucose levels, his chorea persisted. He then received haloperidol at an initial dosage of 1.5 mg/day which was increased to 4.5 mg/day [route not stated]. His chorea had almost completely resolved after 7 days. He continued to receive haloperidol over 10 days and it was then tapered out over a period of 1 week. His chorea recurred 3 days after haloperidol was withdrawn. His blood glucose level was normal. He resumed treatment with haloperidol at the same dose as before but his symptoms persisted. His chorea resolved after treatment with tetrabenazine. Author comment: "Chronic administration of haloperidol can result in the development of dopamine super-sensitivity, and subsequent withdrawal may result in biochemical alterations in the dopaminergic and GABAergic striatal systems." Kim YD, et al. Recurrence of hyperglycemic-induced chorea-ballismus after haloperidol withdrawal. Canadian Journal of Neurological Sciences 38: 663, No. 4, 803062727 Jul 2011 - South Korea
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Reactions 19 Nov 2011 No. 1378
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