Histogenesis and Precursors of Human Gastric Cancer Research and
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Histogenesis and Precursors of
Human Gastric Cancer Research and Practice
With 188 Figures and 45 Tables
Springer-Verlag Berlin Heidelberg NewYork Tokyo
Takeo N agayo Aichi Cancer Center Research Institute 81-1159 Kanokoden, Tashiro-Cho Chikusa-Ku, Nagoya 464 Japan
Library of Congress Cataloging in Publication Data. Nagayo, Takeo, Histogenesis and precursors of human gastric cancer. Includes index. I. Stomach--Cancer. 2. Precancerous conditions. 3. Histology, Pathological. 1. Title. [DNLM: I. Precancerous Conditions. 2. Stomach Neoplasms--pathology. WI 320 NI 52h] RC280.S8N34 1986 616.99'433071 85-27792 ISBN-13: 978-3-642-70363-8 e-ISBN: 13 978-3-642-70361-4 DOl: I0.1 007/978-3-642-70361-4 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to "Verwenungsgesellschaft Won", Munich.
© by Springer-Verlag Berlin Heidelberg 1986 Softcover reprint of the Hardcover 1st edition 1986 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting, printing and bookbinding: Appl, Wemding 2123/3145-543210
Preface
In the summer of 1952, Dr. FUKUZO OHSHIMA, Professor of Pathology at the School of Medicine of Nagoya University, advised me to perform histological examinations of stomachs surgically resected at Yokoyama Hospital for Gastrointestinal Disease. The main purpose of these examinations was to establish the pathological and histological nature of human peptic ulcers as against that of the experimental gastric ulcers we were then trying to induce in rabbits by ligation of all the gastric arteries. During the histological examination of individual resected stomachs - almost all of which were affected by peptic ulcer or gastric cancer - some cases with unusual concomitant mucosal changes apart from the main lesions were encountered. The atypical epithelial features of the lesions were quite suggestive of adenocarcinoma, but owing to lack of knowledge and experience, I asked several colleagues to help me with diagnosis of the histological specimens; unfortunately no satisfactory answers were achieved. In the library, I had examined several papers on the histopathology of early gastric cancer, but to my great regret I was not acquainted at that time with the brilliant articles already published by KONJETZNY, GUTMANN, BERTRAND, and STOuTet al. One day I chanced upon a case report entitled "So-called Mucosal Cancer of the Stomach" [AYABE M (1949) RINSHO TO KENKYU (Clinic and Research) 26: 514-526]. The close similarity of the macroscopical and histological changes in the case in this report with those
