Histopathological and biochemical studies on immunocompetent and immunocompromised Hymenolepis nana infected mice treate
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ORIGINAL ARTICLE
Histopathological and biochemical studies on immunocompetent and immunocompromised Hymenolepis nana infected mice treated with Commiphora molmol (Mirazid) Ahmed Mohamed Sayed Bayoumy1 Mashael Alhumaidi Alotabi2
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Hanan Taher Hamza2,3
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Received: 19 March 2020 / Accepted: 19 August 2020 Indian Society for Parasitology 2020
Abstract Hymenolepiasis is a common parasitic infection of children and considered an opportunistic disease with a life-threatening effect among immunocompromised patients through cysticercoid dissemination. Mirazid (Commiphora molmol) is new phytotherapy for hymenolepiasis. So, the present study aimed to evaluate the effects of Mirazid treatment comparing to Praziquantel (PZQ) (standard treatment) among immunocompetent and immunocompromised infected albino mice through biochemical and histopathological parameters. A total of 60 clean male albino mice (immunocompetent group) were divided into equal five groups which were infected and treated with Mirazid beside PZQ. Another 72 infected immunocompromised animals were divided into equal six groups and were also treated with Mirazid and PZQ. Liver and kidney functions were estimated as well as histopathological examination of intestine and liver. Levels of AST in the serum of infected mice treated with Mirazid or PZQ recorded a highly significant increase compared to the normal control group. The percentage of increase was 83.30% and 36.60% respectively. While the infected group recorded a non-significant decrease in AST level and the percentage of decrease was - 7.4%. Immunocompetent groups showed a positive significant correlation with the control Mirazid or control PZQ groups recorded an & Ahmed Mohamed Sayed Bayoumy [email protected] 1
Department of Medical Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2
Department of Biology, College of Science, Jouf University, P.O.Box: 2014, Sakaka, Saudi Arabia
3
Department of Zoology, Faculty of Science for Girls, AlAzhar University, Cairo, Egypt
increase in liver function enzymes (AST, Bilirubin, and GGT) (P \ 0.001) comparing to the normal control group. In conclusion, Mirazid showed higher cure rates than PZQ, 95.45%, and 74.54% on the 15th and the 21st days, it reached 100% respectively associated with good improvement of histopathological changes in intestine and liver. Keywords H. nana Mice Mirazid Histopathological Biochemical parameters
Introduction Hymenolepiasis is a disease caused by Hymenolepis diminuta (rat tapeworm) and Hymenolepis nana (dwarf tapeworm) (Leder et al. 2013) and has a high prevalence rate in populations in tropical and subtropical countries characterized by poor hygiene and poverty (Kline et al. 2013). Hymenolepis nana (H nana) infection is more common among children and most of the cases pass asymptomatic and self-limited. But symptomatic infections which are mainly noted in heavy infection include abdominal pain, diarrhea, and vomiting (Kandi et al. 2019). It is considered as one of the most common intesti
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