Immunogenetics of Autoimmune Disease
utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and
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Immunogenetics of Autoimmune Disease Jorge Oksenberg, Ph.D. Department of Neurology University of California, San Francisco San Francisco, California, U.S.A.
David Brassat, M.D., Ph.D. Department of Neurology University of California, San Francisco San Francisco, California, U.S.A. and INSERM U563 Toulouse-Purpan, France
LANDES BIOSCIENCE / GEORGETOWN, TEXAS
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SPRINGER SCIENCE+BUSINESS MEDIA NEW YORK, NEW YORK
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IMMUNOGENETICS OF AUTOIMMUNE DISEASE Medical Intelligence Unit Landes Bioscience / Eurekah.com Springer Science+Business Media, LLC ISBN: 0-387-36004-2
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CONTENTS Preface 1. HLA and Autoimmunity: Structural Basis of Immune Recognition Kai W, Wucherpfennig General Structural Features of M H C Class II Molecules Structural Properties of HLA-DR Molecules Associated with Human Autoimmune Diseases Structure and Function of H L A - D Q Molecules That Confer Susceptibility to Type 1 Diabetes and Celiac Disease Presentation of Deamidated Gliadin Peptides by HLA-DQ8 and HLA-DQ2 in Celiac Disease Disease-Associated M H C Class II Molecules and Thymic Repertoire Selection 2.
Genomic Variation and Autoimmune Disease Silke Schmidt and Lis
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