Infective Endocarditis and Other Intravascular Infections
The most important example of intravascular infection is infective endocarditis (IE), a common and serious disorder in man. In the past, these infections were uniformly fatal, but since the development of potent antimicrobial agents, bac teriological cur
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CURRENT TOPICS IN INFECTIOUS DISEASE Series Editors:
William B. Greenough III Division of Geographic Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland
Thomas C. Merigan
Head, Division of Infectious Disease Stanford University Medical Center Stanford, California
The Atypical Mycobacteria and Human Mycobacteriosis
Johns S. Chapman Infections of the Gastrointestinal Tract: Microbiology, Pathophysiology, and Clinical Features
Herbert L. DuPont and Larry K. Pickering Coccidioidomycosis: A Text
Edited by David A. Stevens Cytomegalovirus: Biology and Infection
MontoHo Infective Endocarditis and Other Intravascular Infections
Lawrence R. Freedman
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
Infective Endocarditis and Other Intravascular Infections Lawrence R. Freedman, M.D. VA Wadsworth Medical Center UCLA School oj Medicine Los Angeles, California
PLENUM MEDICAL BOOK COMPANY New York and London
Library of Congress Cataloging in Publication Data Freedman, Lawrence, R. Infective endocarditis and other intravascular infections. (Current topics in infectious disease) Includes index. I. Endocarditis, Bacterial. 2. Blood-vessels-Infections. I. Title. II. Series. [DNLM: I. Endocarditis, Bacterial. 2. Vasculitis. WG 285 F853i] RC685.E5F73 1982 616.1 82-12361 ISBN 978-1-4684-8210-2 ISBN 978-1-4684-8208-9 (eBook) DOl 10.1007/978-1-4684-8208-9
© 1982 Plenum Publishing Corporation Softcover reprint of the hardcover 1st edition 1982
233 Spring Street, New York, N.Y. 10013 Plenum Medical Book Company is an imprint of Plenum Publishing Corporation All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher
To the four women I love and admire Hanna, Julia, Leora, Rina
Acknowledgments I wish to thank the National Institute of Allergy and Infectious Diseases (U.S.P.H.S.) for their support of my studies of intravascular infection while at Yale University, New Haven, Connecticut. I subsequently continued these investigations at the University of Lausanne, Switzerland, at the Centre Hospitalier Universitaire Vaudois, whose support was essential to the work. At this time I am pursuing these studies under the auspices of the Veterans Administration at the VA Wadsworth Medical Center at the University of California at Los Angeles. My thanks go to Mr. Samuel Lunenfeld (Toronto, Canada) and to Professor and Mrs. Franz Joseph (Lausanne, Switzerland) for their help and interest in this project. To Dr. and Mrs. Bruce Rapapport and the Interrnaritime Foundation (Geneva, Switzerland) I want to express deep appreciation for their commitment to medical research and education and for their friendship and generous en
