Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine expos
- PDF / 1,161,394 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 76 Downloads / 154 Views
Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension Jihe Li1 · Dongxia Tong2 · Fuyang Chen3 · Bin Song4 · Ying Wang5 · Yue Liu5 · Xiaohui Zhang5 · Na Liu5 · Yang Xu5 · Yang Li5 · Xinhua Yin5 · Wenxiu Liu5 Accepted: 10 November 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The exact mechanism of the prothrombotic state of essential hypertension (EH) patients remains elusive. Our objective was to assess whether phosphatidylserine (PS) exposure on endothelial cells (ECs), platelets, and microparticles (MPs) can account for the hypercoagulability in EH patients. PS exposure on cells and MPs, mainly from platelets and ECs was analyzed with flow cytometry. Procoagulant activity (PCA) was evaluated by purified coagulation complex assays, clotting time, and fibrin turbidity. We found that EH patients exhibited elevated levels of P S+ platelets, serum-cultured ECs, MPs, endothelial-derived MPs and platelet-derived MPs compared to the controls (all P
Data Loading...
