Innovations in Antiviral Development and the Detection of Virus Infections

THE ERA OF ANTIVIRALS Introduction Although there are more than one hundred medically useful antibiotics and fungicides, there are only seven compounds licensed for use as antiviral agents, in the USA. Some of these (acyclovir and ganciclovir) are actuall

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: N A T H A N B A C K , State University of New York at Buffalo I R U N R. C O H E N , The Weizmann Institute of Science D A V I D K R I T C H E V S K Y , Wistar Institute A B E L L A J T H A , N.S. Kline Institute for Psychiatric Research R O D O L F O P A O L E T T I , University of Milan

Recent Volumes in this Series Volume 309A P U R I N E A N D PYRIMIDINE M E T A B O L I S M IN M A N VII, Part A : Chemotherapy, A T P Depletion, and Gout Edited by R. Angus Harkness, Gertrude B. Elion, and Nepomuk Zöllner Volume 309B P U R I N E A N D PYRIMIDINE M E T A B O L I S M IN M A N VII, Part B: Structural Biochemistry, Pathogenesis, and Metabolism Edited by R. Angus Harkness, Gertrude B. Elion, and Nepomuk Zöllner Volume 310 I M M U N O L O G Y OF M I L K A N D T H E N E O N A T E Edited by Jiri Mestecky, Claudia Blair, and Pearay L . Ogra Volume 311 E X C I T A T I O N - C O N T R A C T I O N C O U P L I N G IN S K E L E T A L , CARDIAC, A N D SMOOTH MUSCLE Edited by George B. Frank, C. Paul Bianchi, and Henk E . D . J . ter Keurs Volume 312 INNOVATIONS IN A N T I V I R A L D E V E L O P M E N T A N D T H E DETECTION OF VIRUS INFECTIONS Edited by Timothy M . Block, Donald Jungkind, Richard Crowell, Mark Denison, and Lori R. Walsh Volume 313 HEPARIN AND RELATED POLYSACCHARIDES Edited by David A . Lane, Ingemar Björk, and U l f Lindahl Volume 314 C E L L - C E L L INTERACTIONS IN T H E R E L E A S E O F I N F L A M M A T O R Y MEDIATORS: Eicosanoids, Cytokines, and Adhesion Edited by Patrick Y - K Wong and Charles N . Serhan Volume 315 T A U R I N E : Nutritional Value and Mechanisms of Action Edited by John B. Lombardini, Stephen W. Schaffer, and Junichi Azuma

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

INNOVATIONS IN ANTIVIRAL DEVELOPMENT AND THE DETECTION OF VIRUS INFECTIONS Edited by

Timothy M. Block and Donald Jimgkind Thomas Jefferson University Hospital Philadelphia, Pennsylvania

Richard L. Crowell Hahnemann University School of Medicine Philadelphia, Pennsylvania

Mark Denison Vanderbilt University Nashville, Tennessee

and

Lori R. Walsh Mercy Catholic Medical Center Darby, Pennsylvania

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L i b r a r y o f Congress C a t a l o g 1 n g - 1 n - P u b l I c a t I o n Data

I n n o v a t i o n s 1n a n t i v i r a l development and the d e t e c t i o n of v i r u s I n f e c t i o n s / e d i t e d by Timothy M. Block ... [ e t a l . ] . p. cm. — (Advances in experimental medicine and b i o l o g y ; v. 312) " P r o c e e d i n g s of the E a s t e r n P e n n s y l v a n i a Branch of the American S o c i e t y f o r M i c r o b i o l o g y Symposium of I n n o v a t i o n s 1n A n t i v i r a l Development and t h e D e t e c t i o n of V i r u s I n f e c t i o n s , h e l d November 15-16, 1990, 1n P h i l a