Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopaus
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ORIGINAL ARTICLE
Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women Johannes D. Veldhuis1 Roy B. Dyer2 Sergey A. Trushin2,3 Olga P. Bondar2 Ravinder J. Singh4 George G. Klee4 ●
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Received: 7 January 2016 / Accepted: 27 June 2016 © Springer Science+Business Media New York 2016
Abstract Available data associate lipids concentrations in men with body mass index, anabolic steroids, age, and certain cytokines. Data were less clear in women, especially across the full adult lifespan, and when segmented by premenopausal and postmenopausal status. Subjects: 120 healthy women (60 premenopausal and 60 postmenopausal) in Olmsted County, MN, USA, a stable well studied clinical population. Dependent variables: measurements of 10 h fasting high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, and triglycerides. Independent variables: testosterone, estrone, estradiol, 5alpha-dihydrotestosterone, and sex-hormone binding globulin (by mass spectrometry); insulin, glucose, and albumin; abdominal visceral, subcutaneous, and total abdominal fat [abdominal visceral fat, subcutaneous fat, total abdominal fat by computerized tomography scan]; and a panel of cytokines (by enzyme-linked immunosorbent assay). Multivariate forward-selection linear-regression analysis was applied constrained to P < 0.01. Lifetime data: High-density lipoprotein cholesterol was correlated jointly with age (P < 0.0001, positively), abdominal visceral fat (P < 0.0001, negatively), and interleukin-6 (0.0063, negatively), together
* Johannes D. Veldhuis [email protected] 1
Endocrine Research Unit, Mayo School of Graduate Medical Education, 200 First Street SW, Rochester, MN 55905, USA
2
Immunochemical Laboratory, 200 First Street SW, Rochester, MN 55905, USA
3
Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
4
Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
explaining 28.1 % of its variance (P = 2.3 × 10−8). Total cholesterol was associated positively with multivariate age only (P = 6.9 × 10−4, 9.3 % of variance). Triglycerides correlated weakly with sex-hormone binding globulin (P = 0.0115), and strongly with abdominal visceral fat (P < 0.0001), and interleukin-6 (P = 0.0016) all positively (P = 1.6 × 10−12, 38.9 % of variance). Non high-density lipoprotein cholesterol and low-density lipoprotein cholesterol correlated positively with both total abdominal fat and interleukin-8 (P = 2.0 × 10−5, 16.9 % of variance; and P = 0.0031, 9.4 % of variance, respectively). Premenopausal vs. postmenopausal comparisons identified specific relationships that were stronger in premenopausal than postmenopausal individuals, and vice versa. Age was a stronger correlate of low-density lipoprotein cholesterol; interleukin-6 of triglycerides and highdensity lipoprotein; and both sex-hormone binding globulin and total abdominal fat of non high-density lipoprotein cholesterol
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