Intra-coronary Imaging for the Evaluation of Plaque Modifications Induced by Drug Therapies for Secondary Prevention
- PDF / 1,270,328 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 214 Views
CORONARY HEART DISEASE (S VIRANI AND S NADERI, SECTION EDITORS)
Intra-coronary Imaging for the Evaluation of Plaque Modifications Induced by Drug Therapies for Secondary Prevention Ismail Dogu Kilic 1 & Enrico Fabris 2 Carlo Di Mario 7
&
Elvin Kedhi 3 & Liviu-Nicolae Ghilencea 4 & Gianluca Caiazzo 5 & Sara Abou Sherif 6 &
Accepted: 16 September 2020 # The Author(s) 2020
Abstract Purpose of Review Patients diagnosed with coronary artery disease are at a high risk of subsequent cardiovascular events; therefore, secondary prevention in the form of therapeutic lifestyle changes, and drug therapies is vital. This article aims to review potential application of intra-coronary imaging for the evaluation of plaque modifications, induced by medications for secondary prevention for CAD. Recent Findings Intra-coronary imaging provides detailed information on the atherosclerotic plaque which is the primary pathological substrate for the recurrent ischemic cardiovascular events. These modalities can detect features associated with high risk and allow serial in vivo imaging of lesions. Therefore, intravascular imaging tools have been used in landmark studies and played a role in improving our understanding of the disease processes. Summary Changes in size and plaque composition over time can be evaluated by these tools and may help understanding the impact of a treatment. Moreover, surrogate imaging end points can be used when testing new drugs for secondary prevention. Keywords Coronary artery disease . Coronary atherosclerosis . Vulnerable plaque . Intra-coronary imaging . Secondary prevention
Introduction
This article is part of the Topical Collection on Coronary Heart Disease * Enrico Fabris [email protected] Carlo Di Mario [email protected] 1
Department of Cardiology, Pamukkale University Hospitals, Denizli, Turkey
2
Cardiovascular Department, University of Trieste, Trieste, Italy
3
Department of Cardiology, Isala Heart Center, Zwolle, the Netherlands
4
University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
5
P.O. San Giuseppe Moscati, Aversa, Italy
6
Brighton and Sussex Medical School, Brighton, UK
7
Cardio-toraco-vascular Department, Careggi University Hospital, Florence, Italy
Patients diagnosed with coronary artery disease (CAD) are at a high risk of subsequent cardiovascular events. Modifications of risk factors can significantly reduce these recurrent events and premature death amongst these patients. For that reason, secondary prevention in the form of therapeutic lifestyle changes, and drug therapies is vital. The evaluation of treatment effect and risk stratification during follow-up is important because this may enable more intensive treatment, motivation and strict follow-up to reduce clinical outcomes. In addition to clinical outcomes, a number of tools are used to evaluate the impact of preventive strategies including biomarkers or imaging modalities. With regard to imaging of coronary atherosclerosis, intravascular modalities are able to provide high-resolution im
Data Loading...
