Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival
- PDF / 1,836,982 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 5 Downloads / 162 Views
CLINICAL STUDY
Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival Henry Ruiz‑Garcia1,2 · Maria T. Huayllani3 · Diego Incontri2 · Juan J. Whaley2 · Lina Marenco‑Hillembrand2 · James Ebot2 · Kaisorn L. Chaichana2 · Jason Sheehan4 · Alfredo Quiñones‑Hinojosa2 · Daniel M. Trifiletti1,2 Received: 28 April 2020 / Accepted: 23 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction Choroid plexus tumors (CPTs) represent one of the most common intraventricular tumors. Although most are benign, they often reach considerable sizes before clinical manifestation, challenging their surgical management. We aim to describe the clinical characteristics and the impact of current management on the survival of patients harboring intraventricular CPT. Methods The National Cancer Database (NCDB) was queried to identify biopsy-proven intraventricular CPT patients (2004–2015). Demographic and patterns of care were described, the log-rank method was used to independently analyze survival according to age, WHO grade and extent of resection (EOR). Multivariate analysis was performed to investigate the impact of prognostic factors on overall survival (OS). Results A total of 439 CPT patients with known WHO grade were included. WHO grade I tumors were more frequent in adults, while WHO grade III tumors were more common in pediatric population. Most CPTs were benign, with a median tumor size of 3–4 cm. Mean tumor size in pediatric population was greater than in adult population (4.39 cm vs. 2.7 cm; p 0.0.5). Five- and ten-year OS among all patients was 87% and 84%, respectively. EOR was not associated with survival for any WHO grade. On multivariable analysis, only patient age (p = 0.022), WHO grade (p = 0.003) and medical comorbidity scores (p = 0.002) were independently associated with OS after diagnosis. Conclusion Patients with CPTs present at different stages of life, with sizable tumor burden and distinct WHO grade prevalence. Considering their favorable survival, efforts to improve tumor control should be meticulously weighed against the long-term risk associated with surgery, radiation, and chemotherapy. Keywords Choroid plexus papilloma · Atypical choroid plexus papilloma · Choroid plexus carcinoma · Prognostic · Epidemiology
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11060-020-03603-8) contains supplementary material, which is available to authorized users. * Daniel M. Trifiletti [email protected] 1
Department of Radiation Oncology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA
2
Department of Neurological Surgery, Mayo Clinic, Jacksonville, FL, USA
3
Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, USA
4
Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
Choroid plexus tumors (CPTs) are rare primary intracrani
Data Loading...
