Levodopa
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Dyskinesias and motor fluctuations: 2 case reports In a case series, a 32-year-old man developed disabling dyskinesia and motor fluctuations, and a 57-year-old man developed dyskinesias and motor fluctuations during treatment with levodopa for Parkinson’s disease (PD). The patients, who had PD, started receiving levodopa [dosages and routes not stated]. However, the patients developed levodopa induced complications consisting disabling/severe dyskinesias and motor fluctuations. Out of these 2 patients, 1 patient developed disabling dyskinesias soon after the initiation of levodopa. The patient also developed motor fluctuations, and considering accompanying fluctuations, sub-thalamic nucleus-deep brain stimulation (STN-DBS) was initiated at the age of 39 years. Another patient developed severe dyskinesias and motor fluctuations by the age of 57 years. Thereafter, this patient was also assigned to STN-DBS [not all time to reactions onsets stated]. After STN-DBS initiation, a significant amelioration of PD symptoms and decrease in levodopa-induced complications were noted in both patients. Gamaleya A, et al. Deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease: Life quality beyond 15 years of follow-up. European Journal of 803498691 Neurology 27 (Suppl. 1): 878 abstr. EPO2184, May 2020. Available from: URL: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14308 [abstract]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 29 Aug 2020 No. 1819
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