Lipids in Protein Misfolding
This book addresses molecular mechanisms of protein misfolding and the role of lipids and related molecules in these complex processes. The focus is on the biophysical and structural studies of proteins that are involved in major human disorders such as A
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Olga Gursky Editor
Lipids in Protein Misfolding
Advances in Experimental Medicine and Biology Volume 855 Editorial Board Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel N.S. Abel Lajtha, Kline Institute for Psychiatric Research, Orangeburg, NY, USA John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Rodolfo Paoletti, University of Milan, Milan, Italy
More information about this series at http://www.springer.com/series/5584
Olga Gursky Editor
Lipids in Protein Misfolding
Editor Olga Gursky Department of Physiology and Biophysics Boston University School of Medicine Boston, MA, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-17343-6 ISBN 978-3-319-17344-3 (eBook) DOI 10.1007/978-3-319-17344-3 Library of Congress Control Number: 2015941281 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
This book addresses the role of lipids in the misfolding of a wide range of proteins, from intrinsically disordered peptides as small as 5 kDa, such as Aβ and amylin, to globular, membrane, and lipid surface-binding proteins as large as apolipoprotein B (550 kDa), which is one of the largest proteins found in nature. The major focus of this compendium is on the biophysical and structural aspects of misfolding of clinically important proteins. Admittedly, the book is biased towards apolipoproteins (apos) and is not comprehensive; for example, prions and several other amyloidogenic proteins such as tau, transthyretin, and immunoglobulin have been left out, leaving plenty of room for the authors of future books. Although volumes have been written on protein misfolding, including two books published by Springer in the Subcellular Biochemistry series
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