Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection
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LETTER
Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection Jingyi Yang1,2 • Ejuan Zhang1,2 • Maohua Zhong1,2 • Qingyu Yang2,3,4 • Ke Hong3,4 • Ting Shu2,3,4 Dihan Zhou1,2 • Jie Xiang3,4 • Jianbo Xia6 • Xi Zhou1,2,3,7 • Dingyu Zhang3,4 • Chaolin Huang3,4 • You Shang3,4,5 • Huimin Yan1,2,7
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Received: 28 June 2020 / Accepted: 24 July 2020 Ó Wuhan Institute of Virology, CAS 2020
Dear Editor, SARS-CoV-2 causes a spectrum of illness, ranging from an asymptomatic state to life-threatening multi-organ failure, and imposes a high socioeconomic burden on its sufferers and on society (Chen et al. 2020; Pan et al. 2020). Asymptomatic SARS-CoV-2 infection, confirmed by assay with quantitative real-time reverse transcription PCR (qRT-PCR), presented neither clinical symptom nor radiographic abnormality (Pan et al. 2020). While T cell responses are crucial for viral control, viral infection also induces significant count decrease and function impairment of T cells (Chen et al. 2020; Qin et al. 2020). Despite high rate of SARS-CoV-2 asymptomatic infections (Black et al. 2020), T cell responses of this population are still largely unknown. Here, we reported the kinetics of CD4? and
Jingyi Yang, Ejuan Zhang and Maohua Zhong have contributed equally to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12250-020-00277-4) contains supplementary material, which is available to authorized users. & Huimin Yan [email protected] & You Shang [email protected] & Chaolin Huang [email protected] 1
Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan 430023, China
2
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, CAS, Wuhan 430071, China
3
Center for Translational Medicine, Jinyintan Hospital, Wuhan 430023, China
CD8? T cell responses in an asymptomatic SARS-CoV-2 infected case. A man in 30s of Hubei resident, who had traveled to Thailand from Wuhan around mid-January, 2020, was tested positive for SARS-CoV-2 upon return to Wuhan on late March and transferred to Wuhan Jinyintan Hospital for isolation. SARS-CoV-2 nucleotide was detected again at days 1–2 in sputum and/or nasopharyngeal swab samples but was undetectable since d5 (Fig. 1A and Supplementary Table S1). SARS-CoV-2-binding IgM was presented in plasma since d7, while IgG remained undetectable at all detected time points (Fig. 1A). These results implied that the man was still at the early stage of virus infection at the time of admission. At day 14 post hospitalization, the man was discharged to a designated hotel for another 14-dayisolation. Within the 28-day follow-up, the man presented neither clinical symptom nor CT abnormality (Supplementary Fig. S1, Supplementary Video S1). Taken togeth
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