Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review o
- PDF / 212,861 Bytes
- 6 Pages / 595.276 x 793.701 pts Page_size
- 70 Downloads / 178 Views
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature Guldeniz Aksan Desteli1*, Murat Gultekin2, Alp Usubutun3, Kunter Yuce4, Ali Ayhan1
Abstract Background: Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia). Methods: A prospective study of clinical stage I ovarian cancer patients is presented. Patient’s characteristics and tumor histopathology were the variables evaluated. Results: Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3. Conclusion: In clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.
Background Epithelial ovarian carcinoma (EOC) is a lethal genital malignancy [1]. Only one third of cases are diagnosed in the early stages of the disease. Lymphadenectomy is an integral part of surgical staging and treatment for ovarian cancers, and they have a potential role in both staging and retroperitoneal debulking. Lymphatic node metastasis results in a change from stage I to stage IIIC. 5-year survival decreases from more than 90% to 20% to 60% if there lymphatic node metastasis is present and adjuvant therapy is needed [2-4]. However, there is debate on the extent of lymphadenectomy, particularly in early staged unilateral tumors (confined to only one ovary) [5,6]. Despite a detailed history of lymphadenectomies in * Correspondence: [email protected] 1 Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Ankara, Turkey Full list of author information is available at the end of the article
scientific literature, there are only a limited number of reports analyzing this topic [5-7]. Furthermore, they are all of a retrospective nature and only include a small number of patients. The staging procedures of these studies and th
Data Loading...
