Management of Myocardial Reperfusion Injury

Much has been written about myocardial reperfusion injury and the controversies surrounding its existence and clinical relevance in the past 20 to 30 years. Unfortunately, however, there is little published information that integrates research findings wi

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Juan Carlos Kaski • Derek J. Hausenloy Bernard John Gersh • Derek M. Yellon Editors

Management of Myocardial Reperfusion Injury

Editors Juan Carlos Kaski, DSc, DM(Hons), M.D., FRCP, FACC, FAHA, FESC Cardiovascular Sciences Research Centre Division of Clinical Sciences St George’s, University of London Cranmer Terrace SW17 ORE London United Kingdom Bernard John Gersh, MB, ChB, D.Phil, FRCP, Ph.D. (Hon Causa) Mayo Clinic Mayo Graduate School of Medicine Dept. Cardiovascular Diseases First Street SW. 200 55905 Rochester Minnesota USA

Derek J. Hausenloy, BSc, MBChB, PhD, FRCP, FESC, FACC Institute of Cardiovascular Science University College London The Hatter Cardiovascular Institute 67 Chenies Mews WC1E 6HX, London United Kingdom Derek M. Yellon, D.Sc., FESC, FACC Institute of Cardiovascular Science University College London The Hatter Cardiovascular Institute 67 Chenies Mews WC1E 6HX, London United Kingdom

ISBN 978-1-84996-018-2 ISBN 978-1-84996-019-9 DOI 10.1007/978-1-84996-019-9 Springer Dordrecht Heidelberg New York London

(eBook)

Library of Congress Control Number: 2012942729 © Springer-Verlag London 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Foreword

During my training in the 1950s and in my early years as a clinical and research cardiologist