Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer
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ORIGINAL ARTICLE – CANCER RESEARCH
Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer Wei Xian1,2,3,4 · Jiayi Shen4 · Huaqiang Zhou1,2,3 · Jiaqing Liu1,2,3 · Yaxiong Zhang1,2,3 · Zhonghan Zhang1,2,3 · Ting Zhou1,2,3 · Shaodong Hong1,2,3 · Yunpeng Yang1,2,3 · Wenfeng Fang1,2,3 · Hongyun Zhao1,2,3 · Yan Huang1,2,3 · Li Zhang1,2,3 Received: 20 June 2020 / Accepted: 22 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer. Methods We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two‐sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer. Results According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88–1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method. Conclusion Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer. Keywords Physical activity · Lung cancer · Causal relationship · Mendelian randomization · Prevention Abbreviations PA Physical activity MR Mendelian randomization Wei Xian, Jiayi Shen and Huaqiang Zhou contributed equally to this work and should be regarded as co-first authors. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00432-020-03409-1) contains supplementary material, which is available to authorized users. * Li Zhang [email protected] 1
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China
2
State Key Laboratory of Oncology in South China, Guangzhou 510060, China
3
Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
4
Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
SNP Single-nucleotide polymorphisms CI Confidence interval GWAS Genome-wide association study IVW Inverse variance weighted
Background According to the estimation of GLOBOCAN, lung cancer covers 11.6% of the total cancer cases and 18.4% of the total cancer deaths, being the most common cancer and prominent cause of cancer death globally (Bray et al. 2018). Physical activity is body movement produced by skeletal muscles that needs energy expenditure according to definition of Worl
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