Meta-analysis of laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma

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Meta‑analysis of laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma Nikolaos Machairas1,2   · Ioannis D. Kostakis2 · Dimitrios Schizas3 · Stylianos Kykalos1 · Nikolaos Nikiteas1 · Georgios C. Sotiropoulos1 Received: 26 July 2020 / Accepted: 11 November 2020 © Italian Society of Surgery (SIC) 2020

Abstract Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive hepatic malignancy. An up-to-date systematic review and meta-analysis was conducted aiming to compare outcomes between laparoscopic (LLR) and open liver resection (OLR) for patients with iCCA. A systematic literature search of Medline, Scopus, Google Scholar, and Cochrane databases was performed. A total of 8 studies comprising 2872 patients, who underwent LLR or OLR for iCCA, were included in our metaanalysis. LLR patients had smaller tumors [mean difference (MD): − 1.17 cm, 95% confidence intervals (CI) − 1.77 to − 0.57, p = 0.0001], underwent major resections less frequently [risk ratio (RR): 0.75, 95% CI 0.67–0.83, p 

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