Methadone abuse
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QTc interval prolongation: case report A 37-year-old man developed QTc interval prolongation following abuse of methadone. The man, who had no smoking history, presented with fatigue, myalgia and dry cough. He was found to be positive with COVID-19 infection. He had a history of methadone abuse, while he denied any recent use of methadone [dosage and route taken not stated]. Due to his symptoms, a chest CT scan was ordered. While entering in the CT scan unit in the radiology department, he suddenly fell down on the ground. Cardio-pulmonary resuscitation was started with chest compression. While fallen on the ground, he had no carotid or distal pulses, had no breathing, and he was pale and unconscious. The man was intubated and ventilation was provided. Then, epinephrine was given. Chest compression was continued and epinephrine was repeated. The latter steps were done while he was on the ground, because there was no opportunity to move him off the ground. Twenty-five minutes later, weak central pulses were detected, with sinus bradycardia rhythm. Later, his condition was more stable and he was moved to the ICU. He had fever, tachycardia and persistent consciousness. Electrocardiogram revealed prolonged QTc interval secondary to the methadone exposure [duration of treatment to reaction onset not stated]. Auscultation of lungs showed diffused rales. CT scan showed moderate right pleural effusion and mild difussed ground glass opacities in the right lower lobe. Additionally, ground glass opacities and patchy air space were noted throughout the both lungs [outcome not stated]. Massoudi N, et al. Sudden cardiac arrest in COVID-19 young patient: A case report. Journal of Cellular and Molecular Anesthesia 5: 122-124, No. 2, Apr 2020. Available 803519455 from: URL: http://doi.org/10.22037/jcma.v5i2.30048
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Reactions 5 Dec 2020 No. 1833
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