Microsized 3D Hydrogel Printing System using Microfluidic Maskless Lithography and Single Axis Stepper Motor
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Original Article
Microsized 3D Hydrogel Printing System using Microfluidic Maskless Lithography and Single Axis Stepper Motor Jinsik Yoon & Wook Park
*
Received: 25 June, 2020 / Accepted: 26 July, 2020 / Published online: 11 September, 2020 ⒸThe Korean BioChip Society and Springer 2020
Abstract The 3D printing apparatus in conventional inkjet and stereolithography systems is limited to continuous fabrication of a microsized three-dimensional hydrogel composed of multiple substances. We present a micro three-dimensional printing system by combining a polydimethylsiloxane microfluidic channel through which various fluids can flow into a micro two-dimensional particle generation system, and a single-axis stepper motor to control the thickness of each layer. The optimal channel designs for micro three-dimensional printing were set up through a physics simulation program and using the simulation analysis, the optimal microfluidic channel was fabricated. Through the system and channel, three-dimensional micropatterns and particles could be fabricated and the generated microparticles automatically collected by the washing flow in the channel. Zinc oxide nanoparticle materials transparent, biocompatible, and capable of absorbing ultraviolet light were added to the premixed photocurable solution used for the microparticle production, and thereby precise micro threedimensional patterns and particles could be fabricated. In addition, by transporting a variety of fluids into the microfluidic channel, it was possible to create micro three-dimensional particles composed of heterogeneous materials. Keywords: 3D printing, Multimaterial, Microfluidics, Microfabrication, Hydrogel Department of Electronics and Information Convergence Engineering, Institute for Wearable Convergence Electronics, Kyung Hee University, 1732, Deogyeongdaero, Giheung, Yongin 17104, Republic of Korea *Correspondence and requests for materials should be addressed to W. Park ( [email protected])
Introduction Microfabrication process technology has helped in the development of microchip systems such as integrated circuits1–3 and microfluidic channel devices4–7. In particular, microfluidic devices have been used where various microstructures or particles are fabricated using flow-focusing and photolithography systems. In the flow-focusing method8–10, spherical microparticles can be produced in large quantities, and special microparticles containing various prepolymers can be produced by flowing heterogeneous materials11,12. The photolithography technique is a method for mass production of various desired two-dimensional microparticles or patterns, and it is used in a variety of fields such as micropatterning13,14 and anti-counterfeiting15. It has also been applied to microfluidic technology and complicated two-dimensional pattern production using various substances16–21. Despite all these studies, demands for more diverse and complex structures have increased, and, simultaneously, the interest in three-dimensional microfabrication has risen. In order to c
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