Midazolam
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Midazolam Urticaria, flushing, pruritus and burning sensation following intranasal administration in children: 3 case reports Three children [sex not stated] aged 4, 5 and 6 years old developed urticaria, flushing, pruritus and burning sensation after receiving intranasal midazolam. The children were scheduled for eye examination under general anaesthesia. They received premedication with the normal IV solution of midazolam 0.7 mg/kg, administered to the nostrils via a 5mL syringe. Five minutes later, and before receiving any other drug, the 6-year-old child developed severe pruritus, burning and pain sensation around the anal region. Ten minutes after receiving midazolam and before receiving any other drug, the other two children developed facial flushing and pruritic urticarial patches on the face around the eyes, and on the neck and body. Subsequently, the children all received general anaesthesia with sevoflurane induction in oxygen and nitrous oxide. The children received IV diphenhydramine and IV prednisolone to treat their symptoms. The urticarial patches resolved. Cold swabbings were applied to the anal region for the anal burning sensation and pruritus. All the children were discharged without complications. Uzun S, et al. Unexpected complications of intranasal midazolam premedication. 801094835 Pediatric Anesthesia 17: 817-818, No. 8, Aug 2007 - Turkey
0114-9954/10/1166-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 25 Aug 2007 No. 1166
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