Molecular and Cellular Biology of Platelet Formation Implications in
This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene t
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lecular and Cellular Biology of Platelet Formation Implications in Health and Disease
Molecular and Cellular Biology of Platelet Formation
Harald Schulze • Joseph Italiano Editors
Molecular and Cellular Biology of Platelet Formation Implications in Health and Disease
Editors Harald Schulze Institute of Experimental Biomedicine I University Hospital Würzburg Würzburg Germany
Joseph Italiano Vascular Biology Programm Harvard Medical School Boston Massachusetts USA
ISBN 978-3-319-39560-9 ISBN 978-3-319-39562-3 (eBook) DOI 10.1007/978-3-319-39562-3 Library of Congress Control Number: 2016960044 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
All cells circulating in the peripheral blood of mammals are derived from a small pool of hematopoietic cells (HSCs) residing in the bone marrow. These HSCs have the potential to develop into all different blood cell lineages, differentiating into different cell types such as hemoglobin-filled red blood cells for gas transport, leukocytes with various functions in innate and adaptive immune responses, or the subcellular fragments – designated blood platelets – with their main function for hemostasis and to prevent blood loss. This differentiation occurs in the presence (or absence) of hematopoietic growth factors like erythropoietin or G-CSF. A similar specific growth factor for platelet formation (as well as for the differentiation from their immediate precursor cells, the megakaryocytes) was already designated as a “thrombopoietin.” For almost 30 years, scientists were searching for this elusive factor. And then finally in 1994, there was a major breakthrough when three seminal discoveries launched the research of this neglected blood lineage: Sever
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