Morbidity and mortality of serious gastrointestinal complications after lung transplantation
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(2019) 14:181
RESEARCH ARTICLE
Open Access
Morbidity and mortality of serious gastrointestinal complications after lung transplantation Annette Zevallos-Villegas1* , Rodrigo Alonso-Moralejo1, Félix Cambra2, Ana Hermida-Anchuelo3, Virginia Pérez-González1, Pablo Gámez-García4, Javier Sayas-Catalán1 and Alicia De Pablo- Gafas1
Abstract Background: Gastrointestinal complications after lung transplatation are associated with an increased risk of morbidity and mortality. This study aims to describe severe gastrointestinal complications (SGC) after lung transplantation. Methods: We performed a prospective, observational study that included 136 lung transplant patients during a seven year period in a tertiary care universitary hospital. SGC were defined as any diagnosis related to the gastrointestinal or biliary tract leading to lower survival rates or an invasive therapeutic procedure. Early and late complications were defined as those occurring < 30 days and ≥ 30 days post-transplant. The survival function was calculated through the Kaplan-Meier estimator. Variables were analyzed using univariate and multivariate analysis. Statistical significance was defined as p < 0.05. Results: There were 17 (12.5%) SGC in 17 patients. Five were defined as early. Twelve patients (70.6%) required surgical treatment. Mortality was 52.9% (n = 9). Patients with SGC had a lower overall survival rate compared to those who did not (14 vs 28 months, p = 0.0099). The development of arrhythmias in the first 48 h of transplantation was a risk factor for gastrointestinal complications (p = 0.0326). Conclusions: SGC are common after lung transplantation and are associated with a considerable increase in morbidity-mortality. Early recognition is necessary to avoid delays in treatment, since a clear predictor has not been found in order to forecast this relevant comorbidity. Keywords: Lung transplantation, Surgical complication, Gastrointestinal complications, Mortality
Background Lung transplantation has now become a standard treatment option in patients with end-stage lung disease. Each year the number of lung transplants increases significantly in the world. A total of 55,795 adult lung transplants have been performed through June 2016. Of these, 2273 (4.1%) were lung retransplantations. Due to the growing experience of specialized centers, the average survival rate has increased to 5.8 years, reaching a 80% survival rate at year 1 and 54% at 5-years * Correspondence: [email protected]; [email protected]; [email protected] 1 Department of Respiratory Medecine, Lung Transplant Unit, “12 de Octubre” University Hospital, “i + 12” Research Institute, Avda de Córdoba s/n, 28041 Madrid, Spain Full list of author information is available at the end of the article
post-transplant [1] due to advances in surgical techniques and immunosuppressive therapy. These improvements have decreased the main immediate complications of lung transplantation, especially extra-thoracic complications, of which gastrointestinal complications are of p
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