Multifunctional ZnO/SiO 2 Core/Shell Nanoparticles for Bioimaging and Drug Delivery Application
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ORIGINAL ARTICLE
Multifunctional ZnO/SiO2 Core/Shell Nanoparticles for Bioimaging and Drug Delivery Application A. P. S. Prasanna 1 & K. S. Venkataprasanna 1 & Balashanmugam Pannerselvam 2 & Vijayshankar Asokan 3 & R. Sofia Jeniffer 4 & G. Devanand Venkatasubbu 1 Received: 29 April 2020 / Accepted: 23 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Semiconducting nanoparticles with luminescent properties are used as detection probes and drug carriers in in-vitro and in-vivo analysis. ZnO nanoparticles, due to its biocompatibility and low cost, have shown potential application in bioimaging and drug delivery. Thus, ZnO/SiO2 core/shell nanoparticle was synthesised by wet chemical method for fluorescent probing and drug delivery application. The synthesised core/shell nanomaterial was characterized using XRD, FTIR, UV-VIS spectroscopy, Raman spectroscopy, TEM and PL analysis. The silicon shell enhances the photoluminescence and aqueous stability of the pure ZnO nanoparticles. The porous surface of the shell acts as a carrier for sustained release of curcumin. The synthesized core/shell particle shows high cell viability, hemocompatibility and promising florescent property. Keywords Bioimaging . Core/shell . Sustainable drug release . Biocompatible
Introduction Bioimaging technique has been widely used to investigate the cellular, physio-chemical functions and morphology with the help of organic dyes and fluorescence proteins [1]. But these organic dyes and protein are highly susceptible to photobleaching, short stokes shift, decomposition and poor photochemical stability due to frequent excitation which makes them unsuitable for long-term cell imaging applications [2, 3]. So, researches have developed different techniques such as magnetic resonance imaging, fluorescence A. P. S. Prasanna and K. S. Venkataprasanna contributed equally to this work. * G. Devanand Venkatasubbu [email protected] 1
Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Chengalpattu District, Tamil Nadu 603 203, India
2
Centre for Nanoscience and Technology, Anna University, Chennai, Tamil Nadu, India
3
Department of Chemistry and Chemical Engineering, Chalmers University, Gothenburg, Sweden
4
Center of Nanotechnology Research (CNR), VIT University, Vellore, Tamilnadu, India
imaging, computed tomography radio imaging, etc., that enables better visualization of cells [4]. The use of luminescent nanomaterial in fluorescence imaging outstands the other techniques due to its high sensitivity, real-time imaging, and minimal-invasiveness. Among them, semiconductor quantum dots such as CdSe and CdTe have been widely used due to its high extinct coefficient, quantum yield, photo-stability, narrow emission, tuneable emission wavelength, and singlesource excitation [5, 6]. But the use of cadmium (Cd) based quantum dots in biological application was limited due to its adverse toxic effect like generation of reactive oxygen species, water-insolubility and releas
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