Neuroimmune Diseases From Cells to the Living Brain
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implic
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Hiroshi Mitoma Mario Manto Editors
Neuroimmune Diseases From Cells to the Living Brain
123
Contemporary Clinical Neuroscience Series editor Mario Manto, Department of Neurology, CHU-Charleroi, Charleroi, Belgium and Department of Neurosciences, University of Mons, Mons, Belgium
More information about this series at http://www.springer.com/series/7678
Hiroshi Mitoma • Mario Manto Editors
Neuroimmune Diseases From Cells to the Living Brain
Editors Hiroshi Mitoma Medical Education Promotion Center Tokyo Medical University Tokyo, Japan
Mario Manto Department of Neurology CHU-Charleroi Charleroi, Belgium Department of Neurosciences University of Mons Mons, Belgium
Contemporary Clinical Neuroscience ISBN 978-3-030-19514-4 ISBN 978-3-030-19515-1 (eBook) https://doi.org/10.1007/978-3-030-19515-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I Fundamental Mechanisms and General Principles Overview of Mechanisms Underlying Neuroimmune Diseases ������������������ 3 Sandip Ashok Sonar and Girdhari Lal Roles of Effector T Cells in Neurological Autoimmunity ���������������������������� 63 Yuki Fujita and Toshihide Yamashita The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders ������������������������������������������������������������������ 83 Arash Pourgholaminejad and Foozhan Tahmasebinia Significance of Autoantibodies������������������������������������������������������������������������ 109 Christiane S. Hampe Immune Tolerance in Autoimmune Central Nervous System Disorders���������������������������������������������������������������������������������������������� 143 Sundararajan Jayarama
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