Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a
- PDF / 9,311,398 Bytes
- 401 Pages / 453.543 x 683.15 pts Page_size
- 79 Downloads / 210 Views
Caroline Fonta László Négyessy Editors
Neuronal TissueNonspecific Alkaline Phosphatase (TNAP)
Subcellular Biochemistry Volume 76
Series editor J. Robin Harris, Mainz, Germany
More information about this series at http://www.springer.com/series/6515
Caroline Fonta László Négyessy •
Editors
Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
123
Editors Caroline Fonta National Centre for Scientific Research (CNRS) University of Toulouse-UPS Toulouse France
László Négyessy Wigner Research Centre for Physics Hungarian Academy of Sciences Budapest Hungary and Department of Anatomy, Histology and Embryology Semmelweis University Medical School Budapest Hungary
ISSN 0306-0225 Subcellular Biochemistry ISBN 978-94-017-7196-2 DOI 10.1007/978-94-017-7197-9
ISBN 978-94-017-7197-9
(eBook)
Library of Congress Control Number: 2015941876 Springer Dordrecht Heidelberg New York London © Springer Science+Business Media Dordrecht 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media B.V. Dordrecht is part of Springer Science+Business Media (www.springer.com)
Preface
Serum alkaline phosphatase (AP) is perhaps the most widely used biomarker since it was discovered in bone tissue by Robison (Biochem. J. 17: 286, 1923). The work by Kay (Brit. J. exp. Path. 10: 253, 1929) and Roberts (Brit. J. exp. Path. 11: 90, 1930) demonstrating elevation of this enzyme in bone and hepatobiliary diseases helped establish the usefulness of this simple enzymatic assay for clinical chemistry. However, most of what we know about the function(s) of this enzyme comes not from the study of clinical conditions displaying increased levels of the enzyme but rather from studying hypophosphatasia (HPP), a life-threatening inborn-error-of-metabolism described by Rathbun (Am J Dis Child 75:822–831, 1943) caused by a deficiency in the expression of the tissue-nonspecific AP (TNAP, a.k.a liver-bone-kidney type AP) isozyme. Fast forward to 2015, we now un
Data Loading...
