Neuropharmacology of New Psychoactive Substances (NPS) The Science B

Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often leg

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Michael H. Baumann Richard A. Glennon Jenny L. Wiley Editors

Neuropharmacology of New Psychoactive Substances (NPS) The Science Behind the Headlines

Current Topics in Behavioral Neurosciences Volume 32

Series editors Mark A. Geyer, La Jolla, CA, USA Bart A. Ellenbroek, Wellington, New Zealand Charles A. Marsden, Nottingham, UK Thomas R.E. Barnes, London, UK

About this Series Current Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats. With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on “translational medicine” and cutting-edge technologies. Preclinical and clinical trials for the development of new diagnostics and therapeutics as well as prevention efforts are covered whenever possible. More information about this series at http://www.springer.com/series/7854

Michael H. Baumann • Richard A. Glennon • Jenny L. Wiley Editors

Neuropharmacology of New Psychoactive Substances (NPS) The Science Behind the Headlines

Editors Michael H. Baumann Designer Drug Research Unit (DDRU) National Institute on Drug Abuse Baltimore, Maryland USA

Richard A. Glennon Department of Medicinal Chemistry Virginia Commonwealth University Richmond, Virginia USA

Jenny L. Wiley RTI International Research Triangle Park North Carolina USA

ISSN 1866-3370 ISSN 1866-3389 (electronic) Current Topics in Behavioral Neurosciences ISBN 978-3-319-52442-9 ISBN 978-3-319-52444-3 (eBook) DOI 10.1007/978-3-319-52444-3 Library of Congress Control Number: 2017937529 © Springer International Publishing AG (outside the USA) 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be tr