Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes
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RESEARCH ARTICLES
Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes Xiaoli Wu1,2 • Mingyue Li3 • Yanfang Zhang1 • Boyun Liang3 • Junming Shi1,2 • Yaohui Fang1,2 • Zhengyuan Su1 • Mengmeng Li3 • Wenjing Zhang3 • Ling Xu3 • Jun Wang1 • Qiaoli Wu1 • Shuang Tang1 Hualin Wang1 • Tao Zhang1 • Cheng Peng3 • Xin Zheng3 • Fei Deng1 • Shu Shen1
•
Received: 8 May 2020 / Accepted: 13 July 2020 Ó Wuhan Institute of Virology, CAS 2020
Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China. This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017. Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains. It was suggested that five different SFTSV genotypes were circulating in Hubei, and 15 reassortment patterns and migration pathways correlated with each genotype were identified, which was more than previously recognized. Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions. Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1. Subsequently, amino acid variations specific for genotype(s), strain(s), or cluster(s) were inspected, which may be related to differential biological activity of SFTSV strains/genotypes. In conclusion, we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution. It provided an in-depth insight into SFTSV evolution, raising concerns for the use of proper SFTSV strains in future studies. Keywords Severe fever with thrombocytopenia syndrome virus (SFTSV) Genotypes Genomic reassortment Virus migration Amino acid variations
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12250-020-00289-0) contains supplementary material, which is available to authorized users. & Shu Shen [email protected] & Fei Deng [email protected] & Xin Zheng [email protected] 1
State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430022, China
Introduction Severe fever with thrombocytopenia syndrome (SFTS) is an emerging se
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