Omeprazole
- PDF / 141,526 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 53 Downloads / 160 Views
1
S
Depression with psychotic features in an elderly patient: case report A 70-year-old woman developed depression with psychotic features following treatment with omeprazole for oesophageal sphincter dysfunction. The woman, who had Sjogren’s syndrome, presented with confusion. She was administered omeprazole for stomach discomfort associated with lower oesophageal sphincter dysfunction [route and dosage not stated]; within the following 2 weeks, her mental status deteriorated and she became vegetative experiencing anhedonia, selfneglect and anorexia. Audio-visual hallucinations were also reported. She was found to be withdrawn, non-verbal and unkempt on examination; a fixation with the death of her family and acquaintances was also noted. Bradykinesia and hyponatraemia with impaired mental status were reported; her mini-mental state exam score was 20/30 with a 2/4 clock drawing. Omeprazole and losartan were withdrawn, and olanzapine was initiated to no avail. Electroconvulsive therapy was performed; the woman’s depression resolved, and she was able to enjoy life again and live independently. Author comment: "This case illustrates the importance of considering unusual pharmacologic side effects as an underlying cause of acute psychotic and depressive symptoms, especially in the elderly patient." Tucker A, et al. When safe is really sad: Omeprazole induced depression with psychotic features. Journal of the American Geriatrics Society 60 (Suppl. 4): 135 abstr. C9, Apr 2012. Available from: URL: http://dx.doi.org/10.1111/ 803072308 j.1532-5415.2012.04000.x - USA
0114-9954/10/1407-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 23 Jun 2012 No. 1407
Data Loading...
