Optimal timing of surgery in infants with prenatally diagnosed isolated left-sided congenital diaphragmatic hernia: a mu

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ORIGINAL ARTICLE

Optimal timing of surgery in infants with prenatally diagnosed isolated left‑sided congenital diaphragmatic hernia: a multicenter, cohort study in Japan Masaya Yamoto1   · Satoko Ohfuji2 · Naoto Urushihara1 · Keita Terui3 · Kouji Nagata4 · Tomoaki Taguchi4 · Masahiro Hayakawa5 · Shoichiro Amari6 · Kouji Masumoto7 · Tadaharu Okazaki8 · Noboru Inamura9 · Katsuaki Toyoshima10 · Keiichi Uchida11 · Taizo Furukawa12 · Manabu Okawada13 · Akiko Yokoi14 · Yukata Kanamori15 · Noriaki Usui16 · Yuko Tazuke17 · Ryuta Saka17 · Hiroomi Okuyama17 on behalf of Japanese Congenital Diaphragmatic Hernia Study Group Received: 28 April 2020 / Accepted: 18 September 2020 © Springer Nature Singapore Pte Ltd. 2020

Abstract Purpose  To date, there is no compelling evidence of the optimal timing of surgery for congenital diaphragmatic hernia (CDH). This study aimed to establish the optimal timing of surgery in neonates with isolated left-sided CDH. Methods  This multicenter cohort study enrolled 276 patients with isolated left-sided CDH at 15 institutions. Based on the timing of surgery, the patients were classified into four groups [