Osteoarthritis Diagnosis and Therapy: Proceedings of an Internat
This volume reviews the state-of-the-art in osteoarthritis. The pathogenetic roles of mechanical, systemic and inflammatory factors and the importance of neurogenic factors in pain management and in the causes of disease are considered. Of particular valu
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Osteoarthritis Diagnosis and Therapy Proceedings of an International Meeting
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
H. Ralph Schumacher jr., MD, Prof. of Medicine University of Pennsylvania, Veterans Administration Medical Center University & Woodland Avenues Philadelphia PA 19104, USA
ISBN -13: 978-3-540-50000-1 DOl: 10.1007/978-3-642-73878-4
e-ISBN-13: 978-3-642-73878-4
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1988 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Product Liability: The Publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Printing and bookbinding: Druckhaus Beltz, 6944 Hemsbach 2127/3140/543210
IV
Table of Contents
Welcome Address R. BERGER . . .
1
Osteoarthrosis (Osteoarthritis) Opening Remarks G. L. BACH . . . . . . . . . .
3
Osteoarthritis: State of the Art H. R. SCHUMACHER, Jr. ...
5
Interaction Between Cartilage Metabolism and Inflammation H. G. FASSBENDER. . . . . . . . . . . .
11
Basic Mechanisms of Pain and Pain Therapy Related to Osteoarthritis and Other Disorders of the Musculoskeletal System M. ZIMMERMANN . . . . . . . . . . .
14
Course of Degenerative Joint Diseases H. MOLLER-FASSBENDER. . . . . . .
29
Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis R. W. MOSKOWITZ. . .
38
Round-Table Discussion
47
Concluding Remarks . .
61
v
List of Contributors
BACH,G.L.
Innere Medizin und Rheumatologie, Klinik HerzoghOhe, Kulmbacher StraBe 103, 8580 Bayreuth
H. G. Zentrum fiir Rheuma-Pathologie, Kleine WindmiihlenstraBe 2 Yto, 6500 Mainz
FASSBENDER,
R. W. Case Western Reserve University, Division of Rheumatic Diseases, University Hospitals, 2073 Abington Road, Cleveland, Ohio 44106, USA
MOSKOWITZ,
MULLER-FASSBENDER, H. II. Medizinische Klinik des Rheumazentrums Bad Abbach, Am Markt 2, 8403 Bad Abbach SCHUMACHER, H. R. University of Pennsylvania, Arthritis-Immunology Center, VAMC, University & Woodland Avenues, Philadelphia PA 19104, USA ZIMMERMANN, M. II. Physiologisches Institut der UniversiHit Heidelberg, 1m Neuenheimer Feld 326,6900
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