Otoprotective Effect of Cortexin, Cogitum, and Elkar Administered Simultaneously with Netromycin in the Experiment
- PDF / 620,417 Bytes
- 5 Pages / 594 x 792 pts Page_size
- 64 Downloads / 150 Views
458
Bulletin of Experimental Biology and Medicine, Vol. 169, No. 4, August, 2020
PHARMACOLOGY AND TOXICOLOGY Otoprotective Effect of Cortexin, Cogitum, and Elkar Administered Simultaneously with Netromycin in the Experiment I. N. D’yakonova1, Yu. S. Ishanova2, and I. V. Rakhmanova2
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 4, pp. 439-443, April, 2020 Original article submitted October 22, 2019 We studied possible otoprotective effect of drugs widely used for the correction of perinatal hypoxic brain damage in premature infants. The experiments were carried out on immature rabbits with an immature hearing organ. The auditory function was assessed by DPOAE and ABR methods in intact animals and rabbits treated with therapeutic doses of netromycin alone or in combination with the drugs that normalize metabolic processes in the brain (Cortexin, Cogitum, Elkar, vitamin B2, ATP, and cocarboxylase). It was found that the administered drugs produced an otoprotective effect and reduced the severity, but did not eliminate the ototoxic effect. Key Words: netromycin; immature hearing organ; otoprotective effect
The organ of hearing in preterm infants is characterized by morphological and functional immaturity at birth and is more vulnerable to the action of pathological factors. Perinatal hypoxia leads to cerebral ischemia and periventricular leukomalacia in 46.6% cases [7,9]. Moreover, dynamic registration of evoked otoacoustic emission in hypoxic-ischemic CNS disorders revealed delayed maturation of the auditory response in all preterm infants during the first year of life [5]. This fact alone requires special attention to the status of the auditory function in those children who have suffered from perinatal hypoxia. The aminoglycoside antibiotics that are prescribed in 95.7% cases to preterm infants [12] make this problem worse. Among aminoglycosides, netromycin ranks second after amikacin by the frequency of administration Department of Physiology, Medical-Biological Faculty, 2Research Laboratory of Clinical and Experimental Child Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia. Address for correspondence: [email protected]. Yu. S. Ishanova 1
for the treatment of infections caused by resistant E. coli and K. pneumonia strains [8,11]. The frequency of hearing impairment in children receiving ototoxic antibiotics is 41.3% [12]. In light of this, the search for drugs that can reduce the ototoxic effect of antibiotics prescribed to premature infants in vital cases becomes relevant. The otoprotective effect of drugs with antioxidant properties is well-known. Thus, it was found that the administration of glutathione to mammals can prevent damage to the outer hair cells which results from the administration of cisplatin [6]. According to experimental data [10], ubiquinone mitoquinone Q derivatives added to the diet of guinea pigs can reduce gentamicin-induced cochlear damage and prevent hearing
Data Loading...
