Paracetamol
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Hepatotoxicity and paediatric acute liver failure in paediatric patients: 2 case reports A retrospective study at a paediatric liver transplant unit of 54 patients with paediatric acute liver failure (PALF) included seven patients who developed PALF secondary to druginduced hepatotoxicity. Four cases involved paracetamol [acetaminophen] toxicity, where the outcome was alive native in 3 patients and died native in 1 patient; an 8-month-old infant and a 2-year-old child were identified. The infant, with fever, had received paracetamol at up to 240 mg/day for 8 days, while the child had received paracetamol 60 mg/kg [indication not stated] for 25 days [sexes and routes not stated; duration of treatment to reaction onsets not clearly stated]. The infant was human herpes virus 6-positive, while the child was human metapneumovirus-positive. Author comment: "Our study reviews 54 children treated for acute liver failure . . . Liver failure secondary to druginduced hepatotoxicity was diagnosed in 7/54 (13%) children . . . Of the four cases of paracetamol toxicity, one child aged eight months received eight days treatment for fever up to 240 mg/kg/day, but was also HHV6 positive. A second patient, aged 2, reportedly received 60 mg/kg paracetamol for 25 days but was also positive for human metapneumovirus". Rajanayagam J, et al. Pediatric acute liver failure: Etiology, outcomes, and the role of serial pediatric end-stage liver disease scores. Pediatric Transplantation 17: 362-368, No. 4, Jun 2013. Available from: URL: http://dx.doi.org/10.1111/ 803095901 petr.12083 - Australia
0114-9954/13/1479-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Reactions 23 Nov 2013 No. 1479
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