Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs

Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery,

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Enno Freye

Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs A Comprehensive Review on their Mode of Action, Treatment of Abuse and Intoxication

In Collaboration with Joseph V. Levy†

Enno Freye, MD, PhD Heinrich-Heine-University Düsseldorf Germany [email protected]

In collaboration with Joseph V. Levy†, PhD University of the Pacific School of Dentistry 2155 Webster St. San Francisco CA 94115 USA

ISBN 978-90-481-2447-3 e-ISBN 978-90-481-2448-0 DOI 10.1007/978-90-481-2448-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009926516 © Springer Science + Business Media B.V. 2009 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written ­permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Contents

Introduction...................................................................................................... Incidence of Illicit Use of Cocaine and Other Drugs.........................................

1 1

Part I  How It All Started with Cocaine...................................................... Botanical Characteristics of Coca Leaves..........................................................

5 7

Production of the Coca Leaf...........................................................................

9

Cocaine: History of Use................................................................................... Coca Consumption with Wine........................................................................... Coca in Refreshing Beverages........................................................................... Regulatories for Use of Cocaine........................................................................

13 15 15 16

Popularity of Cocaine as a Drug for Medical Treatment............................. Use of Cocaine as a Local Anesthetic................................................................ The Different Forms of Cocaine........................................................................

19 21 25

The Different Types of Alkaloids in Coca......................................................

27

The Making of Cocaine in the Jungle............................................................ Steps Refining Coca Paste to Cocaine Base...................................................... Trafficking of Cocaine: The Legal Approach.................................................... Profit Making and Trafficking of Cocaine: The Illegal Approach..................... Smuggling of Cocaine........................................................................................ Diluting or “Cutting” of Cocaine.............