Point-of-care biosensors in medicine: a brief overview of our achievements in this field based on the conducted research
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REVIEW ARTICLE
Point-of-care biosensors in medicine: a brief overview of our achievements in this field based on the conducted research in EMRI (endocrinology and metabolism research Institute of Tehran University of medical sciences) over the past fourteen years Kobra Omidfar 1,2 & Anita Ahmadi 1,2 & Leila Syedmoradi 1,2 & Seyyed Mehdi Khoshfetrat 1,2 & Bagher Larijani 2 Received: 22 September 2020 / Accepted: 19 October 2020 # Springer Nature Switzerland AG 2020
Abstract The growing demand of diagnostic tools with enhanced analytical characteristics in term of sensitivity, selectivity, and low response time has encouraged researches to conduct their research towards development of point-of-care (POC) biosensors. POC diagnostic devices are powerful tools for detection, diagnosis, and monitoring of diseases at its initial stage. The above characteristics encouraged us to conduct active multidisciplinary and collaborative research oriented towards the design and development of POC sensing systems. Here, we present a brief overview of our recent achievement in the field of biomedical POC devices implemented in paper based microfluidic and screen printing electrodes and discuss the critical limitations that need to be surmounted to facilitate their translation into clinical practice in the future. Keywords Point of care testing . Healthcare system . Biosensor . Nano biosensor
Introduction Development of effective diagnostic tools for early detection of clinical biomarkers in body fluids are of great importance, both in detecting disease and physiological signatures that are predictive of potential disease states as early as possible. Although current sensing methods are capable of accurate and specific detection of biomarkers, they are considered unsatisfactory to meet the triple limitations, inherent to biomarker determination, of rapid, low-concentration and inexpensive measurement. These drawbacks were essentially changed by point-of-care biosensor devices. The integration of nanomaterials in point of care testings (POCT) proposes the opportunity of realizing portable, easy to use, cost effective, * Kobra Omidfar [email protected] 1
Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences Institute, Tehran University of Medical Sciences, 14395/1179, Tehran, I.R., Iran
2
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
and miniaturized analytical devices [1]. Such devices enable early disease monitoring and diagnosis, before outbreaks, at the time and place of patient care. POC devices are now becoming popular with interesting applications in the fields of personalized medicine as it can recognize different biomarkers based diseases. These devices were commercialized to diagnose and monitor various disorders such as diabetes, cardiovascular disease, cancer, and infectious diseases [2]. Additionally, the coronavirus disease 2019 (COVID-19) pandemic which affected millions of people arou
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