Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-ind
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ORIGINAL ARTICLE
Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice Chirag Patel 1,2
&
Sonal Pande 1
&
Sanjeev Acharya 1
Received: 27 April 2020 / Accepted: 10 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Curcumin, a major component of Indian saffron through clinical studies, revealed its neuroprotective effect in neurodegenerative diseases. However, it has not been utilized alone orally due to its low bioavailability. There are certain strategies to overcome the drawbacks such as poor absorption and low aqueous solubility. Many strategies are utilized to increase the systemic availability of curcumin. Among them, the steady intestinal and liver metabolism of curcumin by a curcumin adjuvant (enzyme inhibitor/ inducer) is an important and less engrossed strategy for improving the overall systemic bioavailability of curcumin. Here, we assess the effect of probiotic Lactobacillus rhamnosus as a curcumin adjuvant (potentiate the effect of curcumin) in scopolamineinduced dementia in mice. To induce amnesia, scopolamine was used in a mouse model (1 mg/kg, daily for 10 days i.p.). After execution of behavioural tests (Morris water maze test), brains and liver were isolated for further neurochemical and histopathology examination. Our results showed a significant increase in antioxidant enzyme levels in curcumin with a probiotic group compared with curcumin alone. Besides, histopathology study results showed less neuronal damage of curcumin with probiotics as compared with the curcumin and scopolamine alone groups. Additionally, curcumin with probiotics improved memory and cognitive functions in the behavioural study with the significance of p ≤ 0.0001. In conclusion, curcumin with probiotics has greater activity as compared with curcumin alone and reverses the hallmarks of Alzheimer’s disease (AD). Keywords Curcumin . Probiotic . Lactobacillus rhamnosus . Neurodegeneration . Beta-glucuronidase
Introduction AD is an irrevocable brain disorder that degrades neurons and leads to dementia (Weller and Budson 2018). Dementia is a Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00210-020-01904-3) contains supplementary material, which is available to authorized users. * Chirag Patel [email protected] Sonal Pande [email protected] Sanjeev Acharya [email protected] 1
Department of Pharmacology, SSR College of Pharmacy, SSR Memorial Trust, Silvassa, Dadra and Nagar Haveli 396230, India
2
SSR College of Pharmacy, SSR Memorial Trust, Sayli Road, Silvassa, Dadra and Nagar Haveli 396230, India
syndrome that includes amnesia and deterioration in thinking, behaviour, and ability to carry out daily activities (Bondi et al. 2017). Foremost, two histopathological features of AD reported the extracellular accumulation of amyloid-beta plaques (Kametani and Hasegawa 2018) and the formation of neurofibrillary webs (Chesser et al. 201
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