Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps
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Allergy, Asthma & Clinical Immunology Open Access
RESEARCH
Predictive significance of arachidonate 15‑lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps Zhuoping Liang1,2†, Bing Yan1,2,4†, Chang Liu1,2, Ruyu Tan1,2, Chengshuo Wang1,4* and Luo Zhang1,2,3,4*
Abstract Background: Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify effective markers to differentiate ECRSwNP in guiding the treatment strategies of these patients. Although arachidonate 15-lipoxygenase (ALOX15) is positioned as a marker of eosinophilic inflammation, its study in differentiating ECRSwNP has not been reported. The aim of this study is to assess the potential of ALOX15 in distinguishing and predicting ECRSwNP. Methods: Forty-eight patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including 30 ECRSwNP and 18 nonECRSwNP patients, were enrolled. ALOX15 mRNA level was determined in polyps by real-time polymerase chain reaction (RT-PCR). The patients’ baseline characteristics were evaluated and analyzed for correlations with ALOX15. Receiver operating characteristic (ROC) curve was used to assess the predictive significance of the potential predictors for ECRSwNP. Results: ALOX15 mRNA level was significantly higher in ECRSwNP patients than in nonECRSwNP patients (P
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