Pregnancy- and lactation-associated vertebral compression fractures: MRI prevalence and characteristics
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ORIGINAL ARTICLE
Pregnancy- and lactation-associated vertebral compression fractures: MRI prevalence and characteristics A. E. Yıldız 1
&
A. B. Özbalcı 2
&
F. B. Ergen 1
&
Ü. Aydıngöz 1
Received: 23 September 2020 / Accepted: 18 November 2020 # International Osteoporosis Foundation and National Osteoporosis Foundation 2020
Abstract Summary The frequency of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs) is not known. This study showed that MRI prevalence of PLVCFs was approximately 0.5% in females ≥ 15 and < 40 years of age over a 48-month period. PLVCFs did not display MRI features distinguishing them from other vertebral insufficiency fractures. Purpose We aimed to investigate the MRI prevalence and characteristics of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs). Methods This retrospective cross-sectional observational study included all thoracic, lumbar, or thoracolumbar MRI examinations performed in our hospital (or at outside centers and referred to us for consultation) of females ≥ 15 and < 40 years of age during a 48-month period. Two radiologists independently reviewed all images for vertebral compression fractures and their disagreement was resolved by a third blinded senior radiologist with 24 years of dedicated musculoskeletal radiology experience. MRI features of PLVCFs (early/late stage, height loss, endplate involvement, retropulsion) were noted. Results A total of 1484 MRI examinations—including 50 consultations from outside centers—of 1260 females (mean age, 27.7 years; range, 15–39) were included. Interobserver agreement of the two junior radiologists was substantial (κ = 0.607; 95% CI, 0.545–0.669). Vertebral compression fractures were identified in 177 of thoracic (n = 210), lumbar (n = 900), or thoracolumbar MRI (n = 374) examinations. Six women (7 MRI examinations; 4.0% of MRIs with vertebral fractures) had PLVCFs diagnosed on MRI (prevalence, 0.47%; mean age, 31 years; age range, 25–37). Number of fractured vertebrae in cases with PLVCF ranged between 1 and 11 (mean, 5.6). DEXA, available in all patients with PLVCFs, verified osteopenia/osteoporosis in four of six patients. Conclusion PLVCFs have an MRI prevalence of approximately 0.5% in the target population and do not display distinguishing features from other insufficiency type vertebral compression fractures. Keywords Fracture . Lactation . Magnetic resonance imaging . Osteoporosis . Pregnancy
Introduction * A. E. Yıldız [email protected] A. B. Özbalcı [email protected] F. B. Ergen [email protected] Ü. Aydıngöz [email protected] 1
Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100 Ankara, Turkey
2
Department of Radiology, Ondokuz Mayıs University School of Medicine, Atakum, 55139 Samsun, Turkey
Pregnancy- and lactation-associated vertebral compression fractures (PLVCFs) usually occur in the late pregnancy and/ or during the early postpartum period or lactation. The main symptom of PLVCF is acute or chronic back pain that u
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