Prevalence of IA-2 antibody in patients suffering from diabetes and their first-degree relatives
- PDF / 296,328 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 188 Views
ORIGINAL ARTICLE
Prevalence of IA-2 antibody in patients suffering from diabetes and their first-degree relatives Vahid Bolandi 1 & Sepideh Kazemi Azghadi 1 & Mohammadreza Shahami 1 & Mohammad Fereidouni 2 Received: 7 January 2020 / Accepted: 10 October 2020 # Research Society for Study of Diabetes in India 2020
Abstract Background Type 1 diabetes mellitus (T1DM) is an autoimmune disorder accompanied by activation of auto-reactive B cells, autoantibody production, and consequently insulin-producing beta cell destruction. Some evidences support the value of autoantibodies such as anti-islet cell antigen (IA-2) auto-antibody in T1DM diagnosis and prognosis. The present study investigated the presence of IA-2 antibody in T1DM patients and their first-degree relatives as well as T2DM patients and healthy people to evaluate the diagnostic and prognostic value of anti-IA-2 in T1DM. Methods In total 264 cases including 38 T1DM patients, 36 first-degree relatives, 88 T2DM patients, and 102 age-/sex-matched healthy controls participated in this study. After venous blood collection, sera were isolated and the level of IA-2 antibody was measured by ELISA method. Routine hematologic and biochemical tests including complete blood count (CBC), fasting blood sugar (FBS), hemoglobin A1c (HbA1C), urea, creatinine, as well as lipid profile and liver function tests were analyzed. Results Upregulated level of IA-2 antibody was observed in 47.4 and 5.6% of T1DM and their relatives, respectively; however, the level was significantly higher in T1DM compared to T1DM first-degree relatives (p < 0.05). In addition, none of the T2DM patients nor healthy controls were positive for IA-2 autoantibody. There was not any significant correlation between anti-IA-2 levels and total daily dose of insulin and the biochemical and hematological parameters. Conclusion It seems that the measurement of anti-IA-2 antibody has no value in prediction or management of T1DM. Further studies need to reveal the reason for high anti-IA-2 titer in some patients. Keywords Type 1 diabetes mellitus . Autoantibodies . IA-2 antibodies . Biomarkers . Iran
Introduction Type 1 diabetes mellitus (T1DM), which is also known as insulin-dependent diabetes, is caused by a chronic T cell– Vahid Bolandi, Sepideh Kazemi Azghadi and Mohammadreza Shahami contributed equally to this work. * Mohammad Fereidouni [email protected] Vahid Bolandi [email protected] Sepideh Kazemi Azghadi [email protected] Mohammadreza Shahami [email protected] 1
Birjand University of Medical Sciences, Birjand, Iran
2
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
mediated autoimmune demolition of the insulin-producing pancreatic beta cells [1]. Epidemiological surveys have shown an increasing trend in the incidence and prevalence of type 1 diabetes [2–4]. According to the World Health Organization (WHO), diabetes global prevalence among adults has risen to 8.5% of the population, affecting 422 million people in 2014. Moreover, based on the pr
Data Loading...
