Prognostic value of the distance of proximal resection margin in patients who have undergone curative gastric cancer sur
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Prognostic value of the distance of proximal resection margin in patients who have undergone curative gastric cancer surgery HaengJin Ohe1,2, Woo Yong Lee1,2*, Seong Woo Hong2, Yeo Goo Chang2 and Byungmoo Lee2
Abstract Background: We conducted this retrospective study to analyze the relationship between the distance of the proximal resection margin (PRM) and the pattern of recurrence in patients with gastric cancer who underwent curative gastrectomy. Methods: In our series, there were 774 patients who underwent curative gastrectomy for gastric adenocarcinoma. Thus, we classified our clinical series of patients into the distal gastrectomy group (n = 529) and the total gastrectomy group (n = 245). The clinical pathologic data and PRM distance were collected. Univariate and multivariate analyses were performed to evaluate association between PRM distance and locoregional recurrence. Results: The mean distance of the PRM was 4.03 cm in the total gastrectomy group. The distance of the PRM had a significant correlation with advanced T-stage, advanced N-stage,vascular invasion,lymphatic invasion, neural invasion, histological undifferentiation, greater tumor size, and the upper third of the tumor location. On multivariate analysis, tumor recurrence showed only the independent prognostic factor N-stage (P
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