Programmed Cells from Basic Neuroscience to Therapy
The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important
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F. H. Gage Y. Christen (Eds.)
Programmed Cells from Basic Neuroscience to Therapy
123
Research and Perspectives in Neurosciences
For further volumes: http://www.springer.com/series/2357
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Fred H. Gage • Yves Christen Editors
Programmed Cells from Basic Neuroscience to Therapy
Editors Fred H. Gage Laboratory of Genetics The Salk Institute f. Biological Studies La Jolla, California USA
Yves Christen Fondation Ipsen Boulogne Billancourt France
ISSN 0945-6082 ISBN 978-3-642-36647-5 ISBN 978-3-642-36648-2 (eBook) DOI 10.1007/978-3-642-36648-2 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013938743 © Springer-Verlag Berlin Heidelberg 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Programmed Cells from Basic Neuroscience to Therapy
Studies of human brain and neuronal function in phenotypically normal as well as neurological and psychiatric patients have been performed using noninvasive imaging methods. However, the spatial and temporal limitations do not permit single cell/neuron resolution. In addition, genomic and molecular studies of neurological and psychiatric patients are conducted on postmortem tissues often representing the end-stage of life and disease or from peripheral tissues and biopsies, and blood. T
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