Recent Advances in Stem Cells From Basic Research to Clinical Applic
This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron di
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Essam M. Abdelalim Editor
Recent Advances in Stem Cells From Basic Research to Clinical Applications
Stem Cell Biology and Regenerative Medicine
Series Editor Kursad Turksen, Ph.D. [email protected]
More information about this series at http://www.springer.com/series/7896
Essam M. Abdelalim Editor
Recent Advances in Stem Cells From Basic Research to Clinical Applications
Editor Essam M. Abdelalim Qatar Biomedical Research Institute Hamad Bin Khalifa University Doha, Qatar
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-33268-0 ISBN 978-3-319-33270-3 (eBook) DOI 10.1007/978-3-319-33270-3 Library of Congress Control Number: 2016943088 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Stem cells, including pluripotent stem cells (PSCs) and adult stem cells (ASCs), have the ability to differentiate into several cell types, raising the hope for potential understanding and treating incurable human diseases. Despite the short history of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), they are already in clinical trials for some diseases, suggesting a considerable progress in the field of PSCs. The discovery of iPSC technology as well as the recent success in establishment of ESCs using somatic cell nuclear transfer (SCNT) has allowed for the generation of PSCs from somatic cells and has led to the production of in vitro patient-specific PSCs, which have several applications, such as in vitro modeling of different diseases, drug screening, and eventually providing a personalized medicine. On the other hand, ASCs have been in research use for more than 50 years and have been discovered in many organs and tissues. ASCs such as hematopoietic stem cells (HSCs) a
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