Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance
Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a com
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Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance
Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance
Judith Blaine Editor
Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance
Editor Judith Blaine Division of Renal Diseases and Hypertension University of Colorado Denver Aurora, CO, USA
ISBN 978-3-319-43357-8 ISBN 978-3-319-43359-2 DOI 10.1007/978-3-319-43359-2
(eBook)
Library of Congress Control Number: 2016953739 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Introduction
Both albuminuria and proteinuria are sensitive markers of kidney disease and are strongly associated with kidney disease progression and increased risk of cardiovascular events. This volume will describe how albuminuria and proteinuria are measured in the clinical setting, the prognostic implications of increased urinary albumin or protein excretion, and the pathophysiology underlying the development of proteinuria. In addition, diseases or patterns of disease that commonly result in albuminuria or proteinuria will be described as well as the most recent developments in understanding the basic mechanisms underlying these diseases and how these findings have been translated into therapies. While new bench techniques have significantly increased our understanding of how the kidney handles serum proteins, therapeutic options to treat proteinuria are limited, and there is still much progress to be made in developing targeted and effective agents to treat proteinuric renal diseases.
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Contents
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Evaluation and Epidemiology of Proteinuria ......................................... Judith Blaine
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Glomerular Mechanisms of Proteinuria ..................................
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