Psychopharmacoendocrinology and Depression Research
1.1 Outline of the Study In this study the influence of psychotropic drugs on anterior pituitary hormone (APR) secretion was investigated in healthy subjects and in depressed patients. The basis for this study is formed by pharmacological investigations w
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Psychopharmacoendocrinology and Depression Research With 109 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona
Professor Dr. Gregor Laakmann Psychiatrische Klinik der UniversiUit NuBbaumstr. 7 8000 Miinchen 2, FRG
Already published in 1988 under the title: "Psychopharmakoendokrinologie und Depressionsforschung".
ISBN-13: 978-3-540-52075-7
e-ISBN-13 :978-3-642-61290-9
DOl: 10.1007/978-3-642-61290-9 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1990
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check ist accuracy by consulting other pharmaceutical literature. 2125/3130-543210 - Printed on acid-free paper
Acknowledgements
Above all I want to thank Professor Dr. H. Hippius for placing the equipment of this clinic at my disposal and thus enabling me to carry out my investigations. Professor Dr. N. Matussek supported the study by offering his stimulating and positive criticism and by discussing the theoretical basis of the investigation and the assessment of laboratory data. I am gratetful to Professors Dr. Benkert, Dr. Souvatzoglou, Dr. von Werder, and Dr. Muller who introduced me to and stimulated me into doing neuroendocrinological research. I also want to mention the following candidates for doctor's degree B. Flach, B. Frank, T. Guillery, M. Gugath, I. Hofmann, M. Kropp, R. Meissner, T. Munz, E. Neulinger, M. Ortner, H. Schumacher, H. Schon, J. Treusch, U. Treusch, A. WeiB, M. Wittmann, and K. Zygan, who assisted with the examinations. My assistant Dr. A. Hinz was a great help with the evaluation of the examinations and their publications. The statistical evaluation was done by Dipl.-Psych. D. Blaschke, for which I want to express my thanks. Also, I want to thank Mrs. U nterberger for preparing the English version of the text. My office staff assisted in preparing the manuscript. The Deutsche Forschungsgemeinschaft generously supported the examinations described here within the scope of the research program "Neuro-endocrinology", thus rendering them possible. G. Laakmann
Contents
1
Introduction
1
1.1
Outline of the Study
1
1.2
Effect of Psy
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